Joshua Ho, Bioinformatics and Systems Medicine Laboratory, Victor Chang Cardiac Research Institute & UNSW, Sydney

The Ho laboratory focuses on the use of bioinformatics and systems biology approaches to tackle longstanding problems in basic and translational medicine. All projects in this laboratory involve integrative analysis of diverse genome-wide datasets, especially next-generation sequencing (NGS) data such as RNA-seq, ChIP-seq, DNase-seq, and whole genome sequencing data. Multiple projects are available under each theme: (i) reconstruction and analysis of inter-cellular gene regulatory network during mammalian organogenesis; (ii) integrative analysis of epigenomic determinants for cell-type-specific signaling response; (iv) chromatin landscape of fungal epigenomcs; and (iv) causal disease mutation identification using whole genome sequencing data. All projects in this laboratory involve analysis of NGS data. Individual projects can be tailored to fit each team member’s professional interests and skill set. VCCRI has an in-house next-generation sequencer and ample computational resources. The laboratory is also actively involved in a host of exciting collaborations with local and international experimental/clinical collaborators.

Dr. Ho completed a BSc (Hon 1, Medal) in Biochemistry and Computer Science in 2006 and a PhD in Bioinformatics in 2010, both at the University of Sydney. He then completed an interdisciplinary postdoctoral fellowship at the Harvard Medical School (HMS), undertaken jointly in the Computational Genomics Laboratory of A/Professor Peter Park, and the Developmental Genetics Laboratory of Professor Richard Maas. In mid 2012, he became an Instructor in Medicine at HMS. In July 2013, he returned to Australia to set up the Bioinformatics and Systems Medicine Laboratory at the Victor Chang Institute. He is also a conjoint senior lecturer at UNSW.