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Ebrahimie, Esmaeil (The University of Adelaide)

I work on the innovative application of a range of novel bioinformatics, functional genomics, and machine learning approaches in virus, bacteria, plant, mammals, and human genomes. Finding the effective factors in cancer (breast and lung) induction and modeling, protein thermostability, halostability, prediction of function of heavy metal transporters, and application of data mining in determining of influenza virus A subtype and host range are examples of my studies.

My work history includes Adjunct Lecturer in The School of Molecular and Biomedical Science of The University of Adelaide, Assistant Professor at Shiraz University (Institute of Biotechnology and Department of Plant Breeding), Researcher (HEO 5/2) on avian influenza in The School of Animal and Veterinary Sciences of The University of Adelaide and Vavilov-Frankel Research Fellowship at Plant Research Centre (Waite Campus) of The University of Adelaide.

During my collaboration with Research Centre for Infectious Diseases of The University of Adelaide, we analysed systems biology and functional genomics of Streptococcus pneumoniae which causes various diseases such as pneumonia, bacteraemia and meningitis. In particular, we investigated  bacterial transcription factors and regulatory networks which govern the movement of bacteria inside host tissues (nose, lung, blood, and brain). We discovered two novel transcription factors controlling this process and a novel bacterial virulence regulatory network. In addition, we developed the first specialised web application for comparative bacterial Gene Ontology and Gene Ontology-based gene selection in bacteria.

My skill in genomics context includes transcriptomics and proteomics analyses (microarray, EST, microRNAs, domain integration, Prosite etc), designing Gene/protein interaction network, in particular regulatory networks, and next generation data sequencing analyses (RNA-seq, de-novo assembly, SNP discovery, etc).

I think bioinformatics as a fantastic approach which allows imagination to be a hub in science. This novel science is the playground of ideas, and offers new avenues for discovery in science.