My research is centered on proteins: protein structure prediction and modeling; protein folding and design; and protein function prediction and design. This includes discrimination of neural from disease-causing genetic variations. Our group has developed many useful bioinformatics tools for protein structure prediction (SPARKS); secondary structure prediction (SPINE X); intrinsic disorder/semi-disorder prediction (SPINE-D); template-based function prediction (SPOT-DNA/RNA); structural alignment (SPalign); knowledge-based energy function (DFIRE) and etc. All these tools are freely available to academic users at http://sparks-lab.org.
Brief Biography: Dr. Zhou was graduated with a BS in Chemical Physics from University of Science and Technology of China in 1984 and a PhD in Chemical Physics from State University of New York at Stony Brook in 1990. He switched his research field to computational biology when he was a postdoctoral research fellow at Harvard University with Professor Martin Karplus. He became an Assistant Professor in 2000 and Associate Professor in 2004 at Department of Physiology and Biophysics at State University of New York at Buffalo and a full Professor in 2006 when joining Indiana University Schools of Informatics and Medicine at Indianapolis. Starting this year, he joined Institute of Glycomics and School of Information and Communication Technology of Griffith University, Queensland, Australia, as a Professor of Computational Biology.