Andrew Warden - CSIRO

I am research scientist with a strong interest in making closer connections between sequence and structure in bioinformatics (I work primarily on the structure side). My main focus is on molecular dynamics simulations of biological systems, DFT calculations on enzyme substrates, and utilising our rapidly expanding capabilities in these areas to explore the physical and temporal aspects of these systems, in combination with the volumes of sequence information/analysis expertise available, to reveal details of the selective pressures lying behind enzyme evolution. This, in turn, can help to guide efforts in enzyme engineering and beyond that, the design of larger systems containing multiple functional units to carry out tasks ranging from industrial chemical synthesis to targeted drug delivery.