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Friday
Mar102017

Postdoctoral Researchers in Bioinformatics and Computational Biology x2

Applications are invited for two new research positions based in exciting research teams within the Research Division at the Peter MacCallum Cancer Centre:

1. Johnstone Laboratory (Gene Regulation Laboratory). This project will involve the use of genetically engineered mouse models of cancer and human tumor cells to study aberrant transcriptional initiation, elongation and termination in the context of genetic and epigenetic deregulation in cancer

2. Dawson Laboratory (Molecular Biomarkers and Translational Genomics Laboratory). This project will explore the use of circulating tumour DNA analysis to study genomic evolution and provide insights into treatment response and resistance in cancer.

The positions will involve the analysis of large-scale genomic data through the application of best-practice bioinformatics workflows and the development of innovative methods as required. The positions require highly motivated and skilled bioinformaticians or computational biologists with expertise in the analysis of next generation sequencing data, integration of genome-wide datasets, competency in programming languages R and/or Python/Perl and experience with working on a high performance computing cluster. The individuals will collaborate very closely with cancer cell and molecular biologists to work on joint initiatives but will also be responsible for driving their own specified biological projects.

The positions are in a research environment that includes a large and interactive group of bioinformaticians and computational biologists in the Computational Cancer Biology Program and the Bioinformatics Core Facility. 

These positions will be initially offered for a fixed term duration of 12 months with the possible opportunity to extend. Remuneration will be commensurate with qualifications and experience.

Peter Mac offers its employees the following benefits:

  • Salary packaging 
  • Employee Assistance Program 
  • Central City location 
  • Training and Development program

Further details, complete position description and application via here.

Tuesday
Feb282017

Multiple PhD positions (Stem cells, Epigenetics, Gene regulation and Computational Biology) - Monash Biomedicine Discovery Institute, Monash University

Dr. Partha Pratim Das is currently seeking applicants for multiple PhD positions in the field of Stem cells, Epigenetics, Gene regulation and Computational Biology in the Laboratory of “Epigenetics and Gene regulation” within Biomedicine Discovery Institute (BDI), Monash University, Melbourne, Australia.

BDI Monash University is one of the largest and most successful biomedical research institutes in Australia. The BDI brings together more than 100 teams in a highly interactive environment, with access to truly world-class infrastructures. For details, please look at- https://www.monash.edu/discovery-institute

Our laboratory research interest focuses on how transcription factors (TFs) and epigenetic regulators, along with small RNAs and long non-coding RNAs (lncRNAs) regulate gene expression programs in ESCs, neural stem cells and differentiated cells under normal and pathological conditions, such as, cancers and neurodegenerative diseases. We use various experimental approaches including – Cell and Molecular Biology, Biochemistry, CRISPRs, CRISPRs screen (using sgRNAs to target all the genes in the genome, epigenetic regulators and regulatory elements), ChIPs, ChIP-sequencing, RNA-seq, WGS, ATAC-seq, RRBS, ChIA-PET, 3C, 4C, Hi-C, proteomics, bioinformatics and computational biology. For research details, please see: http://www.med.monash.edu.au/anatomy/research/epigenetics-and-gene-regulation.html

Requirements for Molecular Biology students: A strong research background in molecular biology, biochemistry, stem cells and epigenetics are essential. Candidates should be highly motivated and be able to work both independently and in collaborative manner. They should have good communication, organizational, and writing skills.

Requirements for Computational Biology students: The candidates should have computer science, mathematics, statistics, system biology and bioinformatics related backgrounds. They should have excellent communication and writing skills, able to work independently and in teams. Experience working with commonly used bioinformatics tools, as well as on different types of NGS data- ChIP seq, RNA-seq, ATAC-seq would be plus. Candidates will be supervised jointly with my laboratory and Dr. Luca Pinello’s laboratory (http://pinellolab.org) at MGH, Harvard Medical School,Boston. They should expect to spend sometime at MHG during their PhD training at Dr. Pinello’s Lab.

If you are interested, please send a cover letter, CV and contact information for 3 references via email to me-Dr. Partha Pratim Das. PhD (ppdas@bloodgroup.tch.harvard.edu). Applicants must hold a Bachelor’s or equivalent degree with first-class Honours, Master of Science, or MPhil. Our laboratory will be commencing at BDI, Monash University from 1 March, 2017.

Notes: Australian and New Zealand domestic students can be recruited through BDI’s PhD program. International students encouraged applying for Monash-based scholarships support. PhD students will be fully funded during their study. For international students an English proficiency test is required. Our laboratory is committed to diversity and equality.

Click here for further details...

Tuesday
Feb282017

Postdoctoral fellow Bioinformatics and Systems Immunology - UNSW, Kirby Institute

Applications are sought from outstanding researchers for a postdoctoral position bioinformatics in the Viral Immunology Systems Program (VISP) at the Kirby Institute within the University of New South Wales Campus in Sydney, Australia. The researcher who will work in close collaboration with both wet and dry embers of the VISP group to perform bioinformatics and systems Biology analyses in single cell genomics and other data sets. This position will focus on the development and applications of bioinformatics approaches for analyzing and interpreting single cell transcriptomics data, flow cytometry data as well as next generation sequencing data of viral genomes to study immune responses against viral infections, such as HCV, influenza, and other human pathogens. This position will operate at the interface between the Kirby Institute of Infection and Immunity and the School of Medical Sciences, with strong collaborations with the Weizmann Garvan Institute for Cell Genomics.

Required Skills and Experience 

  • PhD in computational biology, mathematics, biostatistics or related fields.
  • Highly developed skills in bioinformatics and/or computational biology.
  • Experience in Genomics and/or transcriptomics analyses.
  • Good knowledge and skills in languages, such as R, Python, C++.
  • Evidence of publications in influential, high-impact journals.
  • Strong communication skills and the ability to work as part of a team.

 


Team

Dr Fabio Luciani lead the computational biology and bioinformatics stream at VISP, and works in close collaboration with members of the VISP team, formed by two post-doctoral fellows in wet-lab analyses, two senior research officers, and 8 PhD students. The VISP works on several projects, including several collaborations nationally and internationally. For more information on the research group, see http://kirby.unsw.edu.au/research-programs/viral-immunology-systems-program/about-program.


Salary

The position is for 1 year, renewable up to 4 years. The net salary will range from Level A step 6 to Level B, depending on expertise, which correspond to a minimum Academic Level A (AUD $89,051 – $95,248 plus 9.5% superannuation p.a.).


Application

The anticipated starting date is January 2017 (but a later start is possible).
 To apply, send within a single PDF a detailed response to the criteria above, current CV, a short statement of research interests, and the name of at least two researchers who can be contacted for reference to luciani@unsw.edu.au


Location

It’s no secret: Sydney is one of the most beautiful, liveable and friendly cities in the world (http://www.sydney.com). The main UNSW campus is located in the eastern suburbs of Sydney only 7km from the centre of the city, 2km from Coogee Beach and 5km from Sydney’s international and domestic airports.

Click here for further details...

Wednesday
Feb222017

Staff positions at Genomics Platform Team, Melbourne

As part of the newly established Center for Cancer Research we have five openings for staff positions in bioinformatics, software engineering and research computing. All positions are funded for three years, and international applicants are welcome to apply. 

You can find additional information at https://umccr.github.io/. If the idea of working on improving cancer health care in a fantastic work environment appeals to you shoot me an email at <oliver.hofmann@unimelb.edu.au> or nudge me on Twitter (@fiamh) even if you do not meet the specific job requirements as additional positions will open soon.

Thursday
Dec012016

One-year postdoctoral position (population genomics) - INRA Angers (France)

One-year postdoctoral position in population genomics at INRA Angers, France
Did host domestication promote pathogen diversification?

Since the beginning of agriculture, hybridization of wild plant with their relatives has led to a generation of new crops with higher agronomic and economic added values. For instance, the dessert apple Malus x domestica is a hybrid between its main contributor, Malus sieversii, endemic in Central Asia and Malus orientalis and Malus sylvestris, respectively endemic in Caucasus and Europe. Alongside the main fungal disease on Malus species caused by the ascomycete Venturia inaequalis also originates Central Asia on M. sieversii and has followed its newly domesticated host toward Europe. V. inaequalis has therefore experienced the many hybridization events of its hosts. Our lab conducts research on the interaction between the scab fungus Venturia inaequalis and its host plants, including domesticated and wild apple trees. Here, we aim at understanding how successive hybridization events between Malus species during apple domestication have modified the pathogenicity determinants of V. inaequalis. Indeed, Although V. inaequalis can infect each Malus species, isolates obtained from the different hosts differ in their virulence. Secreted effector proteins are known to be key determinants of the virulence of fungal pathogens, we will thus focus on the polymorphism of the secretome of V. inaequalis isolated on different Malus species. The polymorphism (including absence/presence) of expressed genes in V. inaequalis populations will then be determined using the 50 genome sequences already available. Coalescence-based analyses will permit to determine the origin of effector alleles that are segregating in strains that infect domestic apple trees. We will test whether new alleles involved in pathogenicity were either introgressed from standing variation preexisting in populations of V. inaequalis on different European and Caucasian wild Malus trees or originated from de novo adaptation. The research will employ interdisciplinary approaches, including pathogenicity data, genomic and RNA-seq analyses. Thanks to the well described evolutionary histories of both V. inaequalis and Malus species, this project will provide new insights into how new fungal pathogens emerge.

Job requirements

Candidates should have obtained a PhD in Biology, genetics, evolutionary ecology, populations genomic. Skills in Next Generation Sequencing data analysis are highly desirable. Experience in coalescent analysis and practical knowledge in bioinformatics are advantageous. Candidates must have proficiency in oral and written English.

Job details

The position is full-time for 12 months.Net salary on appointment will start from €2,100 to €2,500 per month depending on experience. The applicant will have the possibility to obtain an additional mobility allowance from the AgreenSkills+ scheme ranging from €1,300 to €1,700 per month depending on experience. The applicant will be also encouraged to apply to agreenskills to extend their stay by up to 24 months (www.agreenskills.eu).

Application

The position is available to start as soon as possible up to January 2017. Applications should include a cover letter summarizing your experience and describing your research interests, curriculum vitae, and two references. Applications should be emailed to bruno.le-cam@inra.fr For further information, please contact Dr. B. Le Cam (email: bruno.le-cam@inra.fr tel.: +33(0)2-41-22-57-35) or Dr. C. Lemaire (email: Christophe.lemaire@univ-angers.fr)

Organization description

Institut de Recherche en Horticulture et Semences (IRHS) UMR1345 INRA – Université d’Angers – Agro Campus Ouest Evolutionary Ecology of Fungi (EcoFun) 42 rue Georges Morel 49071 Beaucouzé Cedex http://www6.angers-nantes.inra.fr/irhs/Recherche/EcoFun

The candidate will be located in IRHS, Angers, which leads research on ornamentals, fruit trees and seeds in France, including research on fungi that are pathogenic on Rosaceae plants (apple, pear, rose). The candidate will have the opportunity to interact with other research teams within the institute; and will interact with scientists with knowledge in functional genomics, molecular plant pathology, epidemiology and modelling within the EcoFun team.

Life in the Loire Valley

The laboratory is located near Angers, in the Loire Valley. This region is often called the garden of France because of fruits and vegetables production, and green calm landscapes. It is also famous for a gentle way of life, high quality regional food and wines. The banks of the Loire River are very touristic in summer. They offer diverse outdoor activities, from biking to walking in rose gardens and visiting the numerous châteaux.

Click here for further details...

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