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Postdoctoral position in rational protein design - Université Libre de Bruxelles, Belgium

The 3BIO structural bioinformatics group of the Université Libre de Bruxelles, Belgium, is seeking candidates for a postdoctoral position.

Research context: The control of the physicochemical and biological properties of proteins is a major biotechnological challenge. Proteins are increasingly used as catalysts for their high specificity and performance in the development of environment-friendly bioprocesses. Moreover, therapeutic proteins, monoclonal antibodies and protein vaccines are key targets in the biomedical and biopharmaceutical sectors. It has now become possible to develop bioinformatics tools for rationally designing optimized proteins with a good level of accuracy, with the notable advantage compared to purely experimental approaches that the number of experiments for validating candidate mutants is drastically reduced (see Such prediction tools are also applied to get insight into the molecular effects of human variants.

Objective: Design, develop and apply dedicated software for predicting protein stability, solubility and affinity changes upon mutations in the context of rational protein design.

Offer: One full time postdoctoral positions for 2 years with possibility of extension, starting on October 1, 2016, financed by the FNRS Fund for Scientific Research.

Required: PhD degree in Sciences (Bioinformatics, Bioengineer, Physics, Chemistry, Informatics). Excellent programming and computer science skills, preferably in C. Excellent communication skills in English. Publications in peer-reviewed international scientific journals.

Desirable: Experience in the area of protein structural bioinformatics and/or machine learning.

Contact: Please submit a 1) cover letter detailing your background and interest in the position, 2) a full C.V. and 3) at least two references (with name, email, address, phone number) via email to Marianne Rooman and Fabrizio Pucci (mrooman [at] ulb [dot] ac [dot] be, fapucci [at] ulb [dot] ac [dot] be )

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