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Research Engineer (Cancer Genomics, Melbourne)


The University of Melbourne Centre for Cancer Research (UMCCR), led by Professor Sean Grimmond, has the mission to improve cancer patient outcome through genome discovery, translation and personalised medicine. It seeks to achieve this by advancing the molecular detection & diagnosis of cancer, prioritising therapeutic selection via Computational Oncology, and enabling programs in personalised cancer care.
Spanning more than 5000 square meters the UMCCR provides specialist laboratories for cancer cell biology, DNA biobanking, rapid large scale, HTS sequencing and organoid generation and testing. Once fully occupied, the Centre is expected to house more than 260 researchers. It is part of the Victorian Comprehensive Cancer Centre located in the Melbourne Biomedical Precinct, an environment for more than 25 health services, academic research institutes and startups. We are building up a Genomics Platform Team to develop, test and apply accredited bioinformatics workflows to patient data and large scale research projects, evaluating new technologies at a rapid pace.
As part of this team we are hiring an additional Research Engineer to help us drive the development of our sequencing workflow system, bcbio, benchmarking and integrating novel methods into our system. You will work both on local HPC systems and on cloud-environments (AWS, Azure) and coordinate closely with GA4GH Large Scale Genomics and Cloud working groups to align our workflows with international standards. You will collaborate with research computing specialists to resolve computational bottlenecks and work with our international partners to develop emerging CWL/WDL-based infrastructure allowing bcbio and commercial solutions to be deployed on a variety of pipeline management systems such as Toil or Nextflow. Your skills will enable us to process samples from thousands of cancer patients and petabytes of data fast, reliably and reproducibly. Experience with cancer genomics and a strong background in software development are a plus.

* Postgraduate qualification in Computer Science or related discipline with experience in software development or an equivalent combination of relevant experience and
education in software development with a minimum of 3 years’ experience.
* Fluency in at least two programming languages
* Working knowledge of at least one major UNIX platform
* Experience with modern build systems and continuous integration testing
* Ability to rapidly iterate on prototypes while learning new subjects quickly
* Experience with distributed systems and complex infrastructures
* Excellent time management skills and project planning skills
* Effective communication and stakeholder management ability
Start date
As soon as possible
How to Apply
Please see for additional information regarding the Centre, the open positions and the work we do.
Oliver Hofmann,, @fiamh




Bioinformatics Postdoc - Centenary Institute

Cutting Edge Opportunity for a Bioinformatician at an Innovative Research Institute with State-of-the-Art facilities.

Undertake funded research into epigenetics, epitranscriptomics and alternative splicing in normal biology and cancer.

CENTENARY INSTITUTE is a centre of excellence in medical research affiliated with the Royal Prince Alfred Hospital and the University of Sydney.

We are seeking an innovative and enthusiastic bioinformatician to work with a team of researchers in the areas of Epigenetics, Epitranscriptomics, RNA biology and cancer. Building on the recent discoveries we published in Cell, Nature Communications and Blood, we are currently investigating the roles of DNA methylation and RNA modifications in the regulation of alternative splicing in diverse human and mouse cells and tissues. We are also expanding our study to define the interplay between aberrant epigenetic and RNA modifications that contribute to splicing abnormalities relevant to cancers. We are committed to support and mentor young investigators to become group leaders in the future.

Your main role will be to conduct bioinformatics analyses in collaboration with a team of web lab researchers for a fixed term, while participating in the activities of Centenary.

We are looking for exceptional candidates with:

A recent PhD (preferably within the last 12 months) or about to be awarded a PhD in the relevant areas of computational biology/ bioinformatics; Extensive experience in RNAseq data analysis, pipeline development and algorithm implementation/development; Solid research experience, including first author publications in top journals; Ability to write/contribute to journal articles, grants and keep meticulous notes; Strong interpersonal, written and oral communication skills with an ability to liaise with a diverse range of people; A strong team focus; and A demonstrated commitment to Occupational Health and Safety. Desirable:

Experience with WGBS, ChIP-seq and MeRIP-seq data analyses; Familiar with blood cell development and related malignancies, or breast cancers; A demonstrated ability to supervise junior staff and students. CENTENARY offers attractive superannuation and salary packaging to staff. Salary will be dependent on qualifications and experience of the successful candidate.

Contact for the role:

Dr. Justin Wong +61 2 95656175 or

To apply for the role: please email your application to

Applications must include:

  • A cover letter addressing the essential skills,
  • Curriculum vitae (CV) including academic transcript, and
  • Full contact details of at least two recent professional referees.

Closing date: 25 August 2017

Centenary Institute of Cancer Medicine And Cell Biology is a centre of excellence in medical research affiliated with the Royal Prince Alfred Hospital and the University of Sydney located at Camperdown.

For more information about Centenary please visit our website

The Centenary Institute supports Equal Employment Opportunity. We value diversity and encourage applications from women, Aboriginal and Torres Strait Islanders, people with disability, LGBTIQ individuals and applicants of diverse cultures and ages.

Click here for further details...

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